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Selected Publications
Functional correction of CFTR mutations in human airway epithelial cells using adenine base editors. Krishnamurthy S, Traore S, Cooney AL, Brommel CM, Kulhankova K, Sinn PL, Newby GA, Liu DR, McCray PB.Nucleic Acids Res. 2021 Sep 14:gkab788. doi: 10.1093/nar/gkab788. Online ahead of print.PMID: 34520545
Lentiviral vectors transduce lung stem cells without disrupting plasticity. Cooney AL, Thurman AL, McCray PB Jr, Pezzulo AA, Sinn PL.Mol Ther Nucleic Acids. 2021 Jun 24;25:293-301. doi: 10.1016/j.omtn.2021.06.010. eCollection 2021 Sep 3.PMID: 34458011 Free PMC article.
The TMPRSS2 Inhibitor Nafamostat Reduces SARS-CoV-2 Pulmonary Infection in Mouse Models of COVID-19. Li K, Meyerholz DK, Bartlett JA, McCray PB Jr.mBio. 2021 Aug 31;12(4):e0097021. doi: 10.1128/mBio.00970-21. Epub 2021 Aug 3.PMID: 34340553 Free PMC article.
Inter-subject variation in ACE2 protein expression in human airway epithelia and its relationship to SARS-CoV-2 infection. Li K, Wohlford-Lenane C, Bartlett JA, McCray PB.J Infect Dis. 2021 Jul 21:jiab383. doi: 10.1093/infdis/jiab383. Online ahead of print.PMID: 34289058
Protection of K18-hACE2 mice and ferrets against SARS-CoV-2 challenge by a single-dose mucosal immunization with a parainfluenza virus 5-based COVID-19 vaccine. An D, Li K, Rowe DK, Diaz MCH, Griffin EF, Beavis AC, Johnson SK, Padykula I, Jones CA, Briggs K, Li G, Lin Y, Huang J, Mousa J, Brindley M, Sakamoto K, Meyerholz DK, McCray PB Jr, Tompkins SM, He B.Sci Adv. 2021 Jul 2;7(27):eabi5246. doi: 10.1126/sciadv.abi5246. Print 2021 Jul.PMID: 34215591
Increased CFTR expression and function from an optimized lentiviral vector for cystic fibrosis gene therapy. Marquez Loza LI, Cooney AL, Dong Q, Randak CO, Rivella S, Sinn PL, McCray PB Jr.Mol Ther Methods Clin Dev. 2021 Feb 27;21:94-106. doi: 10.1016/j.omtm.2021.02.020. eCollection 2021 Jun 11.PMID: 33768133 Free PMC article.
Structure-based phylogeny identifies avoralstat as a TMPRSS2 inhibitor that prevents SARS-CoV-2 infection in mice. Sun YJ, Velez G, Parsons DE, Li K, Ortiz ME, Sharma S, McCray PB Jr, Bassuk AG, Mahajan VB.J Clin Invest. 2021 May 17;131(10):e147973. doi: 10.1172/JCI147973.PMID: 33844653 Free PMC article.
Integrative chemogenomic analysis identifies small molecules that partially rescue ΔF508-CFTR for cystic fibrosis. Hodos RA, Strub MD, Ramachandran S, Meleshkevitch EA, Boudko DY, Bridges RJ, Dudley JT, McCray PB Jr. CPT Pharmacometrics Syst Pharmacol. 2021 May;10(5):500-510. doi: 10.1002/psp4.12626. Epub 2021 May 2.PMID: 33934548 Free PMC article.
COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice. Zheng J, Wong LR, Li K, Verma AK, Ortiz ME, Wohlford-Lenane C, Leidinger MR, Knudson CM, Meyerholz DK, McCray PB Jr, Perlman S.Nature. 2021 Jan;589(7843):603-607. doi: 10.1038/s41586-020-2943-z. Epub 2020 Nov 9.PMID: 33166988
Integrative genomic meta-analysis reveals novel molecular insights into cystic fibrosis and ΔF508-CFTR rescue. Hodos RA, Strub MD, Ramachandran S, Li L, McCray PB Jr, Dudley JT.Sci Rep. 2020 Nov 25;10(1):20553. doi: 10.1038/s41598-020-76347-0.PMID: 33239626
Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract.
Ortiz ME, Thurman A, Pezzulo AA, Leidinger MR, Klesney-Tait JA, Karp PH, Tan P, Wohlford-Lenane C, McCray PB Jr, Meyerholz DK. EBioMedicine. 2020 Sep 21;60:102976. doi: 10.1016/j.ebiom.2020.102976. Online ahead of print.PMID: 32971472
Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment.
Sun J, Zhuang Z, Zheng J, Li K, Wong RL, Liu D, Huang J, He J, Zhu A, Zhao J, Li X, Xi Y, Chen R, Alshukairi AN, Chen Z, Zhang Z, Chen C, Huang X, Li F, Lai X, Chen D, Wen L, Zhuo J, Zhang Y, Wang Y, Huang S, Dai J, Shi Y, Zheng K, Leidinger MR, Chen J, Li Y, Zhong N, Meyerholz DK,McCray PB Jr, Perlman S, Zhao J. Cell. 2020 Aug 6;182(3):734-743.e5. doi: 10.1016/j.cell.2020.06.010. Epub 2020 Jun 10.PMID: 32643603
A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies.
Hassan AO, Case JB, Winkler ES, Thackray LB, Kafai NM, Bailey AL, McCune BT, Fox JM, Chen RE, Alsoussi WB, Turner JS, Schmitz AJ, Lei T, Shrihari S, Keeler SP, Fremont DH, Greco S, McCray PB Jr, Perlman S, Holtzman MJ, Ellebedy AH, Diamond MS. Cell. 2020 Aug 6;182(3):744-753.e4. doi: 10.1016/j.cell.2020.06.011. Epub 2020 Jun 10.PMID: 32553273
Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract.
Ortiz Bezara ME, Thurman A, Pezzulo AA, Leidinger MR, Klesney-Tait JA, Karp PH, Tan P, Wohlford-Lenane C, McCray PB Jr, Meyerholz DK. bioRxiv. 2020 Jun 1:2020.04.22.056127. doi: 10.1101/2020.04.22.056127. Preprint.PMID: 32577664
Transcriptomic and Proteostasis Networks of CFTR and the Development of Small Molecule Modulators for the Treatment of Cystic Fibrosis Lung Disease.
Strub MD, McCray PB Jr. Genes (Basel). 2020 May 13;11(5):546. doi: 10.3390/genes11050546.PMID: 32414011 Free PMC article. Review.
Single-Dose, Intranasal Immunization with Recombinant Parainfluenza Virus 5 Expressing Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Spike Protein Protects Mice from Fatal MERS-CoV Infection.
Li K, Li Z, Wohlford-Lenane C, Meyerholz DK, Channappanavar R, An D, Perlman S, McCray PB Jr, He B. mBio. 2020 Apr 7;11(2):e00554-20. doi: 10.1128/mBio.00554-20.PMID: 32265331
Engineered amphiphilic peptides enable delivery of proteins and CRISPR-associated nucleases to airway epithelia.
Krishnamurthy S, Wohlford-Lenane C, Kandimalla S, Sartre G, Meyerholz DK, Théberge V, Hallée S, Duperré AM, Del'Guidice T, Lepetit-Stoffaes JP, Barbeau X, Guay D, McCray PB Jr.
Nat Commun. 2019 Oct 28;10(1):4906. doi: 10.1038/s41467-019-12922-y.
Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice.
Li K, Wohlford-Lenane CL, Channappanavar R, Park JE, Earnest JT, Bair TB, Bates AM, Brogden KA, Flaherty HA, Gallagher T, Meyerholz DK, Perlman S, McCray PB Jr.
Proc Natl Acad Sci U S A. 2017 Mar 27. pii: 201619109. doi: 10.1073/pnas.1619109114. [Epub ahead of print]
PMID: 28348219
Proteolytic processing of Middle East respiratory syndrome coronavirus spikes expands virus tropism.
Park JE, Li K, Barlan A, Fehr AR, Perlman S, McCray PB Jr, Gallagher T.
Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12262-12267. Epub 2016 Oct 10.
PMID: 27791014
SYVN1, NEDD8, and FBXO2 Proteins Regulate ΔF508 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Ubiquitin-mediated Proteasomal Degradation.
Ramachandran S, Osterhaus SR, Parekh KR, Jacobi AM, Behlke MA, McCray PB Jr.
J Biol Chem. 2016 Dec 2;291(49):25489-25504. Epub 2016 Oct 18.
PMID: 27756846
Lentiviral-mediated phenotypic correction of cystic fibrosis pigs.
Cooney AL, Abou Alaiwa MH, Shah VS, Bouzek DC, Stroik MR, Powers LS, Gansemer ND, Meyerholz DK, Welsh MJ, Stoltz DA, Sinn PL, McCray PB Jr.
JCI Insight. 2016 Sep 8;1(14). pii: e88730.
PMID: 27656681 Free PMC Article
Novel Innate Immune Genes Regulating the Macrophage Response to Gram Positive Bacteria.
Alper S, Warg LA, De Arras L, Flatley BR, Davidson EJ, Adams J, Smith K, Wohlford-Lenane CL, McCray PB Jr, Pedersen BS, Schwartz DA, Yang IV.
Genetics. 2016 Sep;204(1):327-36. doi: 10.1534/genetics.115.185314. Epub 2016 Jun 29.
PMID: 27356610
Newborn Cystic Fibrosis Pigs Have a Blunted Early Response to an Inflammatory Stimulus.
Bartlett JA, Ramachandran S, Wohlford-Lenane CL, Barker CK, Pezzulo AA, Zabner J, Welsh MJ, Meyerholz DK, Stoltz DA, McCray PB Jr.
Am J Respir Crit Care Med. 2016 Oct 1;194(7):845-854.
PMID: 27027566
Human, Pig, and Mouse Interferon-Induced Transmembrane Proteins Partially Restrict Pseudotyped Lentiviral Vectors.
Hornick AL, Li N, Oakland M, McCray PB Jr, Sinn PL.
Hum Gene Ther. 2016 May;27(5):354-62. doi: 10.1089/hum.2015.156.
PMID: 27004832
Airway acidification initiates host defense abnormalities in cystic fibrosis mice.
Shah VS, Meyerholz DK, Tang XX, Reznikov L, Abou Alaiwa M, Ernst SE, Karp PH, Wohlford-Lenane CL, Heilmann KP, Leidinger MR, Allen PD, Zabner J, McCray PB Jr, Ostedgaard LS, Stoltz DA, Randak CO, Welsh MJ.
Science. 2016 Jan 29;351(6272):503-7. doi: 10.1126/science.aad5589.
PMID: 26823428
Dipeptidyl Peptidase 4 Distribution in the Human Respiratory Tract: Implications for the Middle East Respiratory Syndrome.
Meyerholz DK, Lambertz AM, McCray PB Jr.
Am J Pathol. 2016 Jan;186(1):78-86. doi: 10.1016/j.ajpath.2015.09.014. Epub 2015 Nov 18.
PMID: 26597880
Immunohistochemical Detection of Markers for Translational Studies of Lung Disease in Pigs and Humans.
Meyerholz DK, Lambertz AM, Reznikov LR, Ofori-Amanfo GK, Karp PH, McCray PB Jr, Welsh MJ, Stoltz DA.
Toxicol Pathol. 2015 Oct 27. pii: 0192623315609691. [Epub ahead of print]
PMID: 26511846
Highly differentiated human airway epithelial cells: a model to study host cell-parasite interactions in pertussis.
Guevara C, Zhang C, Gaddy JA, Iqbal J, Guerra J, Greenberg DP, Decker MD, Carbonetti N, Starner TD, McCray PB Jr, Mooi FR, Gómez-Duarte OG.
Infect Dis (Lond). 2015 Oct 22:1-12. [Epub ahead of print]
PMID: 26492208
Middle East Respiratory Syndrome Coronavirus Causes Multiple Organ Damage and Lethal Disease in Mice Transgenic for Human Dipeptidyl Peptidase 4.
Li K, Wohlford-Lenane C, Perlman S, Zhao J, Jewell AK, Reznikov LR, Gibson-Corley KN, Meyerholz DK, McCray PB Jr.
J Infect Dis. 2015 Oct 20. pii: jiv499. [Epub ahead of print]
PMID: 26486634
Increased susceptibility to otitis media in a Splunc1-deficient mouse model.
Bartlett JA, Meyerholz DK, Wohlford-Lenane CL, Naumann PW, Salzman NH, McCray PB Jr.
Dis Model Mech. 2015 May 1;8(5):501-8. doi: 10.1242/dmm.019646. Epub 2015 Mar 12.
PMID: 25765466
The innate immune function of airway epithelial cells in inflammatory lung disease.
Hiemstra PS, McCray PB Jr, Bals R.
Eur Respir J. 2015 Apr;45(4):1150-62. doi: 10.1183/09031936.00141514. Epub 2015 Feb 19.
PMID: 25700381
Ferret and pig models of cystic fibrosis: prospects and promise for gene therapy.
Yan Z, Stewart ZA, Sinn PL, Olsen JC, Hu J, McCray PB Jr, Engelhardt JF.
Hum Gene Ther Clin Dev. 2015 Mar;26(1):38-49. doi: 10.1089/humc.2014.154. Epub 2015 Feb 12.
PMID: 25675143
Platelet Activating Factor Receptor Activation Improves siRNA Uptake and RNAi Responses in Well-differentiated Airway Epithelia.
Krishnamurthy S, Behlke MA, Apicella MA, McCray PB Jr, Davidson BL.
Mol Ther Nucleic Acids. 2014 Jul 15;3:e175. doi: 10.1038/mtna.2014.26.
PMID: 25025465
miR-31 dysregulation in cystic fibrosis airways contributes to increased pulmonary cathepsin S production.
Weldon S, McNally P, McAuley DF, Oglesby IK, Wohlford-Lenane CL, Bartlett JA, Scott CJ, McElvaney NG, Greene CM, McCray PB Jr, Taggart CC.
Am J Respir Crit Care Med. 2014 Jul 15;190(2):165-74. doi: 10.1164/rccm.201311-1986OC.
PMID: 24940638
A genomic signature approach to rescue ΔF508-cystic fibrosis transmembrane conductance regulator biosynthesis and function.
Ramachandran S, Osterhaus SR, Karp PH, Welsh MJ, McCray PB Jr.
Am J Respir Cell Mol Biol. 2014 Sep;51(3):354-62. doi: 10.1165/rcmb.2014-0007OC.
PMID: 24669817
Rapid generation of a mouse model for Middle East respiratory syndrome.
Zhao J, Li K, Wohlford-Lenane C, Agnihothram SS, Fett C, Zhao J, Gale MJ Jr, Baric RS, Enjuanes L, Gallagher T, McCray PB Jr, Perlman S.
Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4970-5. doi: 10.1073/pnas.1323279111. Epub 2014 Mar 5.
PMID: 24599590
Effects of airway surface liquid pH on host defense in cystic fibrosis.
Berkebile AR, McCray PB Jr.
Int J Biochem Cell Biol. 2014 Jul;52:124-9. doi: 10.1016/j.biocel.2014.02.009. Epub 2014 Feb 19. Review.
PMID: 24560894
Receptor variation and susceptibility to Middle East respiratory syndrome coronavirus infection.
Barlan A, Zhao J, Sarkar MK, Li K, McCray PB Jr, Perlman S, Gallagher T.
J Virol. 2014 May;88(9):4953-61. doi: 10.1128/JVI.00161-14. Epub 2014 Feb 19.
PMID: 24554656
piggyBac-mediated phenotypic correction of factor VIII deficiency.
Staber JM, Pollpeter MJ, Arensdorf A, Sinn PL, Rutkowski DT, McCray PB Jr.
Mol Ther Methods Clin Dev. 2014 Sep 10;1:14042. doi: 10.1038/mtm.2014.42. eCollection 2014.
PMID: 26015980
A novel gene delivery method transduces porcine pancreatic duct epithelial cells.
Griffin MA, Restrepo MS, Abu-El-Haija M, Wallen T, Buchanan E, Rokhlina T, Chen YH, McCray PB Jr, Davidson BL, Divekar A, Uc A.
Gene Ther. 2014 Feb;21(2):123-30. doi: 10.1038/gt.2013.62. Epub 2013 Nov 21.
PMID: 24257348
Genotype-specific alterations in vascular smooth muscle cell function in cystic fibrosis piglets.
Guo JJ, Stoltz DA, Zhu V, Volk KA, Segar JL, McCray PB Jr, Roghair RD.
J Cyst Fibros. 2014 May;13(3):251-9. doi: 10.1016/j.jcf.2013.10.009. Epub 2013 Oct 31.
PMID: 24183914
Tracheomalacia is associated with lower FEV1 and Pseudomonas acquisition in children with CF.
Fischer AJ, Singh SB, Adam RJ, Stoltz DA, Baranano CF, Kao S, Weinberger MM, McCray PB Jr,Starner TD.
Pediatr Pulmonol. 2014 Oct;49(10):960-70. doi: 10.1002/ppul.22922. Epub 2013 Oct 25.
PMID: 24166775
Derscheid RJ, van Geelen A, Berkebile AR, Gallup JM, Hostetter SJ, Banfi B, McCray PB Jr, Ackermann MR.
Am J Respir Cell Mol Biol. 2014 Feb;50(2):389-97. doi: 10.1165/rcmb.2012-0529OC.
PMID: 24053146
Person-to-person spread of the MERS coronavirus--an evolving picture.
Perlman S, McCray PB Jr.
N Engl J Med. 2013 Aug 1;369(5):466-7. doi: 10.1056/NEJMe1308724. No abstract available.
PMID: 23902487
piggyBac transposase tools for genome engineering.
Li X, Burnight ER, Cooney AL, Malani N, Brady T, Sander JD, Staber J, Wheelan SJ, Joung JK, McCray PB Jr, Bushman FD, Sinn PL, Craig NL.
Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):E2279-87. doi: 10.1073/pnas.1305987110. Epub 2013 May 30.
PMID: 23723351
Protein composition of bronchoalveolar lavage fluid and airway surface liquid from newborn pigs.
Bartlett JA, Albertolle ME, Wohlford-Lenane C, Pezzulo AA, Zabner J, Niles RK, Fisher SJ, McCray PB Jr, Williams KE.
Am J Physiol Lung Cell Mol Physiol. 2013 Aug 1;305(3):L256-66. doi: 10.1152/ajplung.00056.2013. Epub 2013 May 24.
PMID: 23709621
Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs.
Stoltz DA, Rokhlina T, Ernst SE, Pezzulo AA, Ostedgaard LS, Karp PH, Samuel MS, Reznikov LR, Rector MV, Gansemer ND, Bouzek DC, Alaiwa MH, Hoegger MJ, Ludwig PS, Taft PJ, Wallen TJ, Wohlford-Lenane C, McMenimen JD, Chen JH, Bogan KL, Adam RJ, Hornick EE, Nelson GA 4th, Hoffman EA, Chang EH, Zabner J, McCray PB Jr, Prather RS, Meyerholz DK, Welsh MJ.
J Clin Invest. 2013 Jun;123(6):2685-93. doi: 10.1172/JCI68867. Epub 2013 May 8.
PMID: 23676501
Post-transcriptional regulation of cystic fibrosis transmembrane conductance regulator expression and function by microRNAs.
Ramachandran S, Karp PH, Osterhaus SR, Jiang P, Wohlford-Lenane C, Lennox KA, Jacobi AM, Praekh K, Rose SD, Behlke MA, Xing Y, Welsh MJ, McCray PB Jr.
Am J Respir Cell Mol Biol. 2013 Oct;49(4):544-51. doi: 10.1165/rcmb.2012-0430OC.
PMID: 23646886
Efficient delivery of RNA interference oligonucleotides to polarized airway epithelia in vitro.Ramachandran S, Krishnamurthy S, Jacobi AM, Wohlford-Lenane C, Behlke MA, Davidson BL, McCray PB Jr.
Am J Physiol Lung Cell Mol Physiol. 2013 Jul 1;305(1):L23-32. doi: 10.1152/ajplung.00426.2012. Epub 2013 Apr 26.
PMID: 23624792
SPLUNC1/BPIFA1 contributes to pulmonary host defense against Klebsiella pneumoniae respiratory infection.
Liu Y, Bartlett JA, Di ME, Bomberger JM, Chan YR, Gakhar L, Mallampalli RK, McCray PB Jr, Di YP.
Am J Pathol. 2013 May;182(5):1519-31. doi: 10.1016/j.ajpath.2013.01.050. Epub 2013 Mar 15.
PMID: 23499554
Intrapulmonary Versus Nasal Transduction of Murine Airways With GP64-pseudotyped Viral Vectors.
Oakland M, Maury W, McCray PB Jr, Sinn PL.
Mol Ther Nucleic Acids. 2013 Jan 29;2:e69. doi: 10.1038/mtna.2012.60.
PMID: 23360952
A Hyperactive Transposase Promotes Persistent Gene Transfer of a piggyBac DNA Transposon.Burnight ER, Staber JM, Korsakov P, Li X, Brett BT, Scheetz TE, Craig NL, McCray PB Jr.
Mol Ther Nucleic Acids. 2012 Oct 16;1:e50. doi: 10.1038/mtna.2012.12.
PMID: 23344650
Manipulation of Cell Physiology Enables Gene Silencing in Well-differentiated Airway Epithelia.
Krishnamurthy S, Behlke MA, Ramachandran S, Salem AK, McCray PB Jr, Davidson BL.
Mol Ther Nucleic Acids. 2012 Aug 28;1:e41. doi: 10.1038/mtna.2012.36.
PMID: 23344182
Lentiviral vector gene transfer to porcine airways.
Sinn PL, Cooney AL, Oakland M, Dylla DE, Wallen TJ, Pezzulo AA, Chang EH, McCray PB Jr.
Mol Ther Nucleic Acids. 2012 Nov 27;1:e56. doi: 10.1038/mtna.2012.47.
PMID: 23187455
Intranasal treatment with poly(I•C) protects aged mice from lethal respiratory virus infections.
Zhao J, Wohlford-Lenane C, Zhao J, Fleming E, Lane TE, McCray PB Jr, Perlman S.
J Virol. 2012 Nov;86(21):11416-24. doi: 10.1128/JVI.01410-12. Epub 2012 Aug 22.
PMID: 22915814
A microRNA network regulates expression and biosynthesis of wild-type and DeltaF508 mutant cystic fibrosis transmembrane conductance regulator.
Ramachandran S, Karp PH, Jiang P, Ostedgaard LS, Walz AE, Fisher JT, Keshavjee S, Lennox KA, Jacobi AM, Rose SD, Behlke MA, Welsh MJ, Xing Y, McCray PB Jr.
Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13362-7. doi: 10.1073/pnas.1210906109. Epub 2012 Aug 1.
PMID: 22853952
Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung.
Pezzulo AA, Tang XX, Hoegger MJ, Alaiwa MH, Ramachandran S, Moninger TO, Karp PH, Wohlford-Lenane CL, Haagsman HP, van Eijk M, Bánfi B, Horswill AR, Stoltz DA, McCray PB Jr, Welsh MJ, Zabner J.
Nature. 2012 Jul 4;487(7405):109-13. doi: 10.1038/nature11130.
PMID: 22763554
Sinus hypoplasia precedes sinus infection in a porcine model of cystic fibrosis.
Chang EH, Pezzulo AA, Meyerholz DK, Potash AE, Wallen TJ, Reznikov LR, Sieren JC, Karp PH, Ernst S, Moninger TO, Gansemer ND, McCray PB Jr, Stoltz DA, Welsh MJ, Zabner J.
Laryngoscope. 2012 Sep;122(9):1898-905. doi: 10.1002/lary.23392. Epub 2012 Jun 18.
PMID: 22711071
Pancreatic damage in fetal and newborn cystic fibrosis pigs involves the activation of inflammatory and remodeling pathways.
Abu-El-Haija M, Ramachandran S, Meyerholz DK, Abu-El-Haija M, Griffin M, Giriyappa RL, Stoltz DA, Welsh MJ, McCray PB Jr, Uc A.
Am J Pathol. 2012 Aug;181(2):499-507. doi: 10.1016/j.ajpath.2012.04.024. Epub 2012 Jun 8.
PMID: 22683312
CFTR is required for maximal transepithelial liquid transport in pig alveolar epithelia.
Li X, Comellas AP, Karp PH, Ernst SE, Moninger TO, Gansemer ND, Taft PJ, Pezzulo AA, Rector MV, Rossen N, Stoltz DA, McCray PB Jr, Welsh MJ, Zabner
J. Am J Physiol Lung Cell Mol Physiol. 2012 Jul;303(2):L152-60. doi: 10.1152/ajplung.00116.2012. Epub 2012 May 25.
PMID: 22637155
Transcriptional targeting in the airway using novel gene regulatory elements.
Burnight ER, Wang G, McCray PB Jr, Sinn PL.
Am J Respir Cell Mol Biol. 2012 Aug;47(2):227-33. doi: 10.1165/rcmb.2011-0444OC. Epub 2012 Mar 23.
PMID: 22447971
Advances in cell and gene-based therapies for cystic fibrosis lung disease.
Oakland M, Sinn PL, McCray PB Jr.
Mol Ther. 2012 Jun;20(6):1108-15. doi: 10.1038/mt.2012.32. Epub 2012 Feb 28. Review.
PMID: 22371844
Future directions in early cystic fibrosis lung disease research: an NHLBI workshop report.
Ramsey BW, Banks-Schlegel S, Accurso FJ, Boucher RC, Cutting GR, Engelhardt JF, Guggino WB, Karp CL, Knowles MR, Kolls JK, LiPuma JJ, Lynch S, McCray PB Jr, Rubenstein RC, Singh PK, Sorscher E, Welsh M.
Am J Respir Crit Care Med. 2012 Apr 15;185(8):887-92. doi: 10.1164/rccm.201111-2068WS. Epub 2012 Feb 3.
PMID: 22312017
An activated immune and inflammatory response targets the pancreas of newborn pigs with cystic fibrosis.
Abu-El-Haija M, Sinkora M, Meyerholz DK, Welsh MJ, McCray PB Jr, Butler J, Uc A.
Pancreatology. 2011;11(5):506-15. doi: 10.1159/000332582. Epub 2011 Nov 1.
PMID: 22057257
Adherens junction protein nectin-4 is the epithelial receptor for measles virus.
Mühlebach MD, Mateo M, Sinn PL, Prüfer S, Uhlig KM, Leonard VH, Navaratnarajah CK, Frenzke M, Wong XX, Sawatsky B, Ramachandran S, McCray PB Jr, Cichutek K, von Messling V, Lopez M, Cattaneo R.
Nature. 2011 Nov 2;480(7378):530-3. doi: 10.1038/nature10639.
PMID: 22048310
Quantitation of SPLUNC1 in saliva with an xMAP particle-based antibody capture and detection immunoassay.
Kohlgraf KG, Ackermann AR, Burnell KK, Srikantha RN, Joly SA, Bartlett JA, Gakhar L, Johnson GK, McCray PB Jr, Guthmiller JM, Brogden KA.
Arch Oral Biol. 2012 Feb;57(2):197-204. doi: 10.1016/j.archoralbio.2011.08.013. Epub 2011 Sep 16.
PMID: 21925642
PLUNC: a multifunctional surfactant of the airways.
Bartlett JA, Gakhar L, Penterman J, Singh PK, Mallampalli RK, Porter E, McCray PB Jr.
Biochem Soc Trans. 2011 Aug;39(4):1012-6. doi: 10.1042/BST0391012. Erratum in: Biochem Soc Trans. 2011 Oct;39(5):1549. Bartlett, Jennifer [corrected to Bartlett, Jennifer A]; Singh, Pradeep [corrected to Singh, Pradeep K].
PMID: 21787339
Microarray mRNA expression profiling to study cystic fibrosis.
Ramachandran S, Clarke LA, Scheetz TE, Amaral MD, McCray PB Jr.
Methods Mol Biol. 2011;742:193-212. doi: 10.1007/978-1-61779-120-8_12.
PMID: 21547734
T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus.
Kondratowicz AS, Lennemann NJ, Sinn PL, Davey RA, Hunt CL, Moller-Tank S, Meyerholz DK, Rennert P, Mullins RF, Brindley M, Sandersfeld LM, Quinn K, Weller M, McCray PB Jr, Chiorini J, Maury W.
Proc Natl Acad Sci U S A. 2011 May 17;108(20):8426-31. doi: 10.1073/pnas.1019030108. Epub 2011 May 2.
PMID: 21536871
Tyrosine kinase receptor Axl enhances entry of Zaire ebolavirus without direct interactions with the viral glycoprotein.
Brindley MA, Hunt CL, Kondratowicz AS, Bowman J, Sinn PL, McCray PB Jr, Quinn K, Weller ML, Chiorini JA, Maury W.
Virology. 2011 Jul 5;415(2):83-94. doi: 10.1016/j.virol.2011.04.002. Epub 2011 May 6.
PMID: 21529875
Current prospects for RNA interference-based therapies.
Davidson BL, McCray PB Jr.
Nat Rev Genet. 2011 May;12(5):329-40. doi: 10.1038/nrg2968. Review.
PMID: 21499294
Altering α-dystroglycan receptor affinity of LCMV pseudotyped lentivirus yields unique cell and tissue tropism.
Dylla DE, Xie L, Michele DE, Kunz S, McCray PB Jr.
Genet Vaccines Ther. 2011 Apr 8;9:8. doi: 10.1186/1479-0556-9-8.
PMID: 21477292
Criterion for amino acid composition of defensins and antimicrobial peptides based on geometry of membrane destabilization.
Schmidt NW, Mishra A, Lai GH, Davis M, Sanders LK, Tran D, Garcia A, Tai KP, McCray PB,Ouellette AJ, Selsted ME, Wong GC.
J Am Chem Soc. 2011 May 4;133(17):6720-7. doi: 10.1021/ja200079a. Epub 2011 Apr 7.
PMID: 21473577
Enhancement of respiratory mucosal antiviral defenses by the oxidation of iodide.
Fischer AJ, Lennemann NJ, Krishnamurthy S, Pócza P, Durairaj L, Launspach JL, Rhein BA, Wohlford-Lenane C, Lorentzen D, Bánfi B, McCray PB Jr.
Am J Respir Cell Mol Biol. 2011 Oct;45(4):874-81. doi: 10.1165/rcmb.2010-0329OC. Epub 2011 Mar 25.
PMID: 21441383
Genetic therapies for cystic fibrosis lung disease.
Sinn PL, Anthony RM, McCray PB Jr.
Hum Mol Genet. 2011 Apr 15;20(R1):R79-86. doi: 10.1093/hmg/ddr104. Epub 2011 Mar 21. Review.
PMID: 21422098
The ΔF508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs.
Ostedgaard LS, Meyerholz DK, Chen JH, Pezzulo AA, Karp PH, Rokhlina T, Ernst SE, Hanfland RA, Reznikov LR, Ludwig PS, Rogan MP, Davis GJ, Dohrn CL, Wohlford-Lenane C, Taft PJ, Rector MV, Hornick E, Nassar BS, Samuel M, Zhang Y, Richter SS, Uc A, Shilyansky J, Prather RS, McCray PB Jr, Zabner J, Welsh MJ, Stoltz DA.
Sci Transl Med. 2011 Mar 16;3(74):74ra24. doi: 10.1126/scitranslmed.3001868.
PMID: 21411740
Concentration of the antibacterial precursor thiocyanate in cystic fibrosis airway secretions.
Lorentzen D, Durairaj L, Pezzulo AA, Nakano Y, Launspach J, Stoltz DA, Zamba G, McCray PB Jr, Zabner J, Welsh MJ, Nauseef WM, Bánfi B.
Free Radic Biol Med. 2011 May 1;50(9):1144-50. doi: 10.1016/j.freeradbiomed.2011.02.013. Epub 2011 Feb 18.
PMID: 21334431
A microRNA-regulated and GP64-pseudotyped lentiviral vector mediates stable expression of FVIII in a murine model of Hemophilia
A. Matsui H, Hegadorn C, Ozelo M, Burnett E, Tuttle A, Labelle A, McCray PB Jr, Naldini L, Brown B, Hough C, Lillicrap D.
Mol Ther. 2011 Apr;19(4):723-30. doi: 10.1038/mt.2010.290. Epub 2011 Feb 1.
PMID: 21285959
Pigs and humans with cystic fibrosis have reduced insulin-like growth factor 1 (IGF1) levels at birth.
Rogan MP, Reznikov LR, Pezzulo AA, Gansemer ND, Samuel M, Prather RS, Zabner J, Fredericks DC, McCray PB Jr, Welsh MJ, Stoltz DA.
Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20571-5. doi: 10.1073/pnas.1015281107. Epub 2010 Nov 8.
PMID: 21059918
The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia.
Pezzulo AA, Starner TD, Scheetz TE, Traver GL, Tilley AE, Harvey BG, Crystal RG, McCray PB Jr, Zabner J.
Am J Physiol Lung Cell Mol Physiol. 2011 Jan;300(1):L25-31. doi: 10.1152/ajplung.00256.2010. Epub 2010 Oct 22.
PMID: 20971803
Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children.
Meyerholz DK, Stoltz DA, Namati E, Ramachandran S, Pezzulo AA, Smith AR, Rector MV, Suter MJ, Kao S, McLennan G, Tearney GJ, Zabner J, McCray PB Jr, Welsh MJ.
Am J Respir Crit Care Med. 2010 Nov 15;182(10):1251-61. doi: 10.1164/rccm.201004-0643OC. Epub 2010 Jul 9.
PMID: 20622026
Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth.
Stoltz DA, Meyerholz DK, Pezzulo AA, Ramachandran S, Rogan MP, Davis GJ, Hanfland RA, Wohlford-Lenane C, Dohrn CL, Bartlett JA, Nelson GA 4th, Chang EH, Taft PJ, Ludwig PS, Estin M, Hornick EE, Launspach JL, Samuel M, Rokhlina T, Karp PH, Ostedgaard LS, Uc A, Starner TD, Horswill AR, Brogden KA, Prather RS, Richter SS, Shilyansky J, McCray PB Jr, Zabner J, Welsh MJ.
Sci Transl Med. 2010 Apr 28;2(29):29ra31. doi: 10.1126/scitranslmed.3000928.
PMID: 20427821
PLUNC is a novel airway surfactant protein with anti-biofilm activity.
Gakhar L, Bartlett JA, Penterman J, Mizrachi D, Singh PK, Mallampalli RK, Ramaswamy S, McCray PB Jr.
PLoS One. 2010 Feb 9;5(2):e9098. doi: 10.1371/journal.pone.0009098.
PMID: 20161732
Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae.
O'Keefe BR, Giomarelli B, Barnard DL, Shenoy SR, Chan PK, McMahon JB, Palmer KE, Barnett BW, Meyerholz DK, Wohlford-Lenane CL, McCray PB Jr.
J Virol. 2010 Mar;84(5):2511-21. doi: 10.1128/JVI.02322-09. Epub 2009 Dec 23. Erratum in: J Virol. 2010 May;84(10):5456.
PMID: 20032190
The use of carboxymethylcellulose gel to increase non-viral gene transfer in mouse airways.
Griesenbach U, Meng C, Farley R, Wasowicz MY, Munkonge FM, Chan M, Stoneham C, Sumner-Jones SG, Pringle IA, Gill DR, Hyde SC, Stevenson B, Holder E, Ban H, Hasegawa M, Cheng SH, Scheule RK, Sinn PL, McCray PB Jr, Alton EW.
Biomaterials. 2010 Mar;31(9):2665-72. doi: 10.1016/j.biomaterials.2009.12.005. Epub 2009 Dec 21.
PMID: 20022367
Integrase-defective lentiviral vectors: progress and applications.
Banasik MB, McCray PB Jr.
Gene Ther. 2010 Feb;17(2):150-7. doi: 10.1038/gt.2009.135. Epub 2009 Oct 22. Review.
PMID: 19847206
Differential effects of cytokines and corticosteroids on toll-like receptor 2 expression and activity in human airway epithelia.
Winder AA, Wohlford-Lenane C, Scheetz TE, Nardy BN, Manzel LJ, Look DC, McCray PB Jr.
Respir Res. 2009 Oct 16;10:96. doi: 10.1186/1465-9921-10-96.
PMID: 19835594
Rhesus theta-defensin prevents death in a mouse model of severe acute respiratory syndrome coronavirus pulmonary disease.
Wohlford-Lenane CL, Meyerholz DK, Perlman S, Zhou H, Tran D, Selsted ME, McCray PB Jr.
J Virol. 2009 Nov;83(21):11385-90. doi: 10.1128/JVI.01363-09. Epub 2009 Aug 26.
PMID: 19710146
Progress and prospects: prospects of repeated pulmonary administration of viral vectors.
Sinn PL, Burnight ER, McCray PB Jr.
Gene Ther. 2009 Sep;16(9):1059-65. doi: 10.1038/gt.2009.87. Epub 2009 Jul 30. Review.
PMID: 19641533
Rho GTPases modulate entry of Ebola virus and vesicular stomatitis virus pseudotyped vectors.
Quinn K, Brindley MA, Weller ML, Kaludov N, Kondratowicz A, Hunt CL, Sinn PL, McCray PB Jr, Stein CS, Davidson BL, Flick R, Mandell R, Staplin W, Maury W, Chiorini JA.
J Virol. 2009 Oct;83(19):10176-86. doi: 10.1128/JVI.00422-09. Epub 2009 Jul 22.
PMID: 19625394
Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia.
Jia HP, Look DC, Tan P, Shi L, Hickey M, Gakhar L, Chappell MC, Wohlford-Lenane C, McCray PB Jr.
Am J Physiol Lung Cell Mol Physiol. 2009 Jul;297(1):L84-96. doi: 10.1152/ajplung.00071.2009. Epub 2009 May 1.
PMID: 19411314
The piglet as a model for B cell and immune system development.
Butler JE, Lager KM, Splichal I, Francis D, Kacskovics I, Sinkora M, Wertz N, Sun J, Zhao Y, Brown WR, DeWald R, Dierks S, Muyldermans S, Lunney JK, McCray PB, Rogers CS, Welsh MJ, Navarro P, Klobasa F, Habe F, Ramsoondar
J. Vet Immunol Immunopathol. 2009 Mar 15;128(1-3):147-70. doi: 10.1016/j.vetimm.2008.10.321. Epub 2008 Nov 1. Review.
PMID: 19056129
Cytokine-mediated regulation of antimicrobial proteins.
Kolls JK, McCray PB Jr, Chan YR.
Nat Rev Immunol. 2008 Nov;8(11):829-35. doi: 10.1038/nri2433. Review.
PMID: 18949018
Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs.
Rogers CS, Stoltz DA, Meyerholz DK, Ostedgaard LS, Rokhlina T, Taft PJ, Rogan MP, Pezzulo AA, Karp PH, Itani OA, Kabel AC, Wohlford-Lenane CL, Davis GJ, Hanfland RA, Smith TL, Samuel M, Wax D, Murphy CN, Rieke A, Whitworth K, Uc A, Starner TD, Brogden KA, Shilyansky J, McCray PB Jr, Zabner J, Prather RS, Welsh MJ.
Science. 2008 Sep 26;321(5897):1837-41. doi: 10.1126/science.1163600.
PMID: 18818360
Lentivirus vector can be readministered to nasal epithelia without blocking immune responses.
Sinn PL, Arias AC, Brogden KA, McCray PB Jr.
J Virol. 2008 Nov;82(21):10684-92. doi: 10.1128/JVI.00227-08. Epub 2008 Sep 3.
PMID: 18768988
Differential gene expression in human conducting airway surface epithelia and submucosal glands.
Fischer AJ, Goss KL, Scheetz TE, Wohlford-Lenane CL, Snyder JM, McCray PB Jr.
Am J Respir Cell Mol Biol. 2009 Feb;40(2):189-99. doi: 10.1165/rcmb.2008-0240OC. Epub 2008 Aug 14.
PMID: 18703793
Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification.
Maeder ML, Thibodeau-Beganny S, Osiak A, Wright DA, Anthony RM, Eichtinger M, Jiang T, Foley JE, Winfrey RJ, Townsend JA, Unger-Wallace E, Sander JD, Müller-Lerch F, Fu F, Pearlberg J, Göbel C, Dassie JP, Pruett-Miller SM, Porteus MH, Sgroi DC, Iafrate AJ, Dobbs D, McCray PB Jr,Cathomen T, Voytas DF, Joung JK.
Mol Cell. 2008 Jul 25;31(2):294-301. doi: 10.1016/j.molcel.2008.06.016.
PMID: 18657511
Measles virus blind to its epithelial cell receptor remains virulent in rhesus monkeys but cannot cross the airway epithelium and is not shed.
Leonard VH, Sinn PL, Hodge G, Miest T, Devaux P, Oezguen N, Braun W, McCray PB Jr,McChesney MB, Cattaneo R.
J Clin Invest. 2008 Jul;118(7):2448-58. doi: 10.1172/JCI35454.
PMID: 18568079
Innate immune functions of the airway epithelium.
Bartlett JA, Fischer AJ, McCray PB Jr.
Contrib Microbiol. 2008;15:147-63. doi: 10.1159/000136349. Review.
PMID: 18511860
The porcine lung as a potential model for cystic fibrosis.
Rogers CS, Abraham WM, Brogden KA, Engelhardt JF, Fisher JT, McCray PB Jr, McLennan G, Meyerholz DK, Namati E, Ostedgaard LS, Prather RS, Sabater JR, Stoltz DA, Zabner J, Welsh MJ. Am J Physiol Lung Cell Mol Physiol. 2008 Aug;295(2):L240-63. doi: 10.1152/ajplung.90203.2008. Epub 2008 May 16. Review.
PMID: 18487356
Basolateral entry and release of New and Old World arenaviruses from human airway epithelia.
Dylla DE, Michele DE, Campbell KP, McCray PB Jr.
J Virol. 2008 Jun;82(12):6034-8. doi: 10.1128/JVI.00100-08. Epub 2008 Apr 16.
PMID: 18417570
PLUNC is a secreted product of neutrophil granules.
Bartlett JA, Hicks BJ, Schlomann JM, Ramachandran S, Nauseef WM, McCray PB Jr.
J Leukoc Biol. 2008 May;83(5):1201-6. doi: 10.1189/jlb.0507302. Epub 2008 Feb 1.
PMID: 18245229
MD-2-dependent pulmonary immune responses to inhaled lipooligosaccharides: effect of acylation state.
Hadina S, Weiss JP, McCray PB Jr, Kulhankova K, Thorne PS.
Am J Respir Cell Mol Biol. 2008 Jun;38(6):647-54. doi: 10.1165/rcmb.2007-0418OC. Epub 2008 Jan 18.
PMID: 18203970